Improved Synthesis of Antimycin A3
نویسندگان
چکیده
منابع مشابه
Improved Synthesis of Vasicinone
A new, high yielding method for the preparation of vasicinone (7) is described. Reaction of 2-nitrobenzoic acid with N, N¢-carbonyldiimidazole followed by 2-pyrrolidinone gave 1-(2-nitrobenzoyl)pyrrolidine-2-one (3). Reduction of the latter with 10% Pd-C afforded deoxyvasicinone (4). Reaction of deoxyvasicinone (4) with bromine yielded monobromo-deoxyvasicinone (5). Exchange of bro...
متن کاملimproved synthesis of vasicinone
a new, high yielding method for the preparation of vasicinone (7) is described. reaction of 2-nitrobenzoic acid with n, n¢-carbonyldiimidazole followed by 2-pyrrolidinone gave 1-(2-nitrobenzoyl)pyrrolidine-2-one (3). reduction of the latter with 10% pd-c afforded deoxyvasicinone (4). reaction of deoxyvasicinone (4) with bromine yielded monobromo-deoxyvasicinone (5). exchange of bromine of 5 wit...
متن کاملIn Silico Study and Cytotoxicity of the Synthesized Open-chain Analogues of Antimycin A3 Against HEP-2 Laryngeal Cancer Cells
Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Student of Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Synthetic Organic Chemistry Laboratory, Graduate School of Materials Science, Nara Institute of Science and Technolog...
متن کاملGreen and efficient synthesis of propargylamines via A3 coupling reaction using a copper (II)–thioamide combination
A one pot green three‐component coupling reaction of aldehyde, phenylacetylene, and amine derivatives in the presence of copper (II)–thioamide combination as a novel and efficient heterogeneous catalyst under solvent–free conditions is reported. The catalyst displayed high activity and afforded the corresponding propargylamines in good to high yields. The key to this procedure was the generatio...
متن کاملThe synthesis of a series of adenosine A3 receptor agonists.
A series of 1'-(6-aminopurin-9-yl)-1'-deoxy-N-methyl-β-d-ribofuranuronamides that were characterised by 2-dialkylamino-7-methyloxazolo[4,5-b]pyridin-5-ylmethyl substituents on N6 of interest for screening as selective adenosine A3 receptor agonists, have been synthesised. This work involved the synthesis of 2-dialkylamino-5-aminomethyl-7-methyloxazolo[4,5-b]pyridines and analogues that were cou...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1979
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.52.198